Chemotherapy May Trigger More Aggressive Tumours.
Breast cancer is one of the most common tumour types, and metastasis greatly increases the risk of death from this disease. By studying the process of intravasation or entry of cells into the vasculature, Karagiannis et al. discovered that, in addition to killing tumour cells, chemotherapy treatment can also increase intravasation. Groups of cells collectively known as tumour microenvironment of metastasis (TMEM) can serve as gateways for tumour cells entering the vasculature, and the authors discovered that several types of chemotherapy can increase the amounts of TMEM complexes and circulating tumour cells in the bloodstream. The researchers also determined that a drug called rebastinib can interfere with TMEM activity and help overcome the increased risk of cancer cell dissemination. Credit: Research Article on Neoadjuvant Chemotherapy Induces Breast Cancer Metastasis Through a TMEM-Mediated Mechanism, 5 July 2017 at Science Translational Medicine.
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