Major Finding In Human Anatomy Has Implications For Many Brain Diseases

Major Finding In Human Anatomy Has Implications For Many Brain Diseases.

This is a series of scientific breakthroughs in terms of brain chemistry and how it affects our anatomy, much more than had previously been thought possible. It concerns a branch of the lymphatic system called the glymphatic system that permeates the brain. The name “glymphatic system” was coined by the Danish neuroscientist Maiken Nedergaard in recognition of its dependence upon glial cells and the similarity of its functions to those of the peripheral lymphatic system. The glymphatic system or glymphatic clearance pathway, is a functional waste clearance pathway for the vertebrate central nervous system. The pathway consists of a para-arterial influx route for cerebrospinal fluid (CSF) to enter the brain parenchyma, coupled to a clearance mechanism for the removal of interstitial fluid (ISF) and extracellular solutes from the interstitial compartments of the brain and spinal cord. Exchange of solutes between the CSF and the ISF is driven by arterial pulsation and regulated during sleep by the expansion and contraction of brain extracellular space. Clearance of soluble proteins, waste products, and excess extracellular fluid is accomplished through convective bulk flow of the ISF, facilitated by astrocytic aquaporin 4 water channels.

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