The Curse of the People Who Never Feel Pain.
Congenital insensitivity to pain is a condition, present from birth that inhibits the ability to perceive physical pain. Affected individuals are unable to feel pain in any part of their body. People with this condition can feel the difference between sharp and dull and hot and cold, but cannot sense, for example, that a hot beverage is burning their tongue. Over time, this lack of pain awareness can lead to an accumulation of injuries and health issues that may affect life expectancy. Congenital insensitivity to pain is caused by mutations in the SCN9A gene and, in rare cases, is caused by mutations in the PMRD 12 gene. It is inherited in an autosomal recessive pattern. It is considered a form of peripheral neuropathy because it affects the peripheral nervous system, which connects the brain and spinal cord to muscles and to cells that detect sensations such as touch, smell, and pain. This article introduces us to this rare disorder, profiling a few individuals.
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