How Can We Stop Cancer Cells From Spreading?
Uncontrolled cell proliferation is a hallmark of cancer that leads to the development of primary tumours, which may be followed by further progression to metastasis, the spread of cancer cells from a primary organ to distal sites. Cell proliferation and migration are two key drivers of metastasis that are regulated by complex interactions of multiple pathways that can either concurrently or divergently stimulate the two processes. Some studies have shown that the two processes occur simultaneously; proliferation and migration are both stimulated by secreted factors such as fibroblast growth factors. Other studies suggest that the two processes are mutually exclusive; primary tumour cells proliferate uncontrollably with tight cell-cell junction and low mobility, while metastatic invasive tumour cells seem to delay proliferation during migration. Scientists at the John Hopkins University, led by Hasini Jayatilaka, found a mix of medication that stopped deliver of this process.
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