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Saturday, 20 January, 2018
Phages Caught Sending Chemical Messages.

Phages Caught Sending Chemical Messages

Phages Caught Sending Chemical Messages.

Rotem Sorek and his colleagues at the Weizmann Institute of Science in Rehovot, Israel, published in Nature their paper entitled Communication Between Viruses Guides Lysis-Lysogeny Decisions on 18 January 2017.

Viruses can become dormant in their host cells, a process called lysogeny. In every infection, such viruses decide between the lytic and the lysogenic cycles, that is, whether to replicate and lyse their host or to lysogenize and keep the host viable. In their research, the viruses (phages) of the SPbeta group use a small-molecule communication system to coordinate lysis–lysogeny decisions. During infection of its Bacillus host cell, the phage produces a six amino-acids-long communication peptide that is released into the medium. In subsequent infections, progeny phages measure

the concentration of this peptide and lysogenize if the concentration is sufficiently high. We found that different phages encode different versions of the communication peptide, demonstrating a phage-specific peptide communication code for lysogeny decisions. We term this communication system the ‘arbitrium’ system, and further show that it is encoded by three phage genes: aimP, which produces the peptide; aimR, the intracellular peptide receptor; and aimX, a negative regulator of lysogeny. The arbitrium system enables a descendant phage to ‘communicate’ with its predecessors, that is, to estimate the amount of recent previous infections and hence decide whether to employ the lytic or lysogenic cycle.

Read Article Here:

http://www.nature.com/news/do-you-speak-virus-phages-caught-sending-chemical-messages-1.21313

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